Reduced airway vagal tone in diabetic patients with autonomic neuropathy.
نویسندگان
چکیده
1. Forced expiratory flow rates and specific airways conductance were measured before and after the inhalation of the atropine-like drug ipratropium bromide in 11 diabetic patients with autonomic neuropathy and a control group of 11 diabetic patients without autonomic neuropathy. Respiratory muscle function was assessed by recording maximal inspiratory and expiratory mouth pressures. 2. There was no difference between the two groups of diabetic patients in airway calibre before ipratropium bromide or in maximal mouth pressures. 3. Bronchodilatation after ipratropium bromide was greater in the control group than in the autonomic neuropathy group of patients. 4. It is concluded that, despite the lack of clinical evidence of respiratory involvement, patients with diabetic autonomic neuropathy have reduced airway vagal tone.
منابع مشابه
Impaired Circadian Modulation of Sympathovagal Activity in Diabetes
Background. Diabetic subjects have a high incidence of cardiovascular accidents, with an altered circadian distribution. Abnormalities in the circadian rhythm of autonomic tone may be responsible for this altered temporal onset of cardiovascular disease. Methods and Results. To assess circadian changes of sympathovagal balance in diabetes, we performed 24-hour power spectral analysis of RR inte...
متن کاملImpaired circadian modulation of sympathovagal activity in diabetes. A possible explanation for altered temporal onset of cardiovascular disease.
BACKGROUND Diabetic subjects have a high incidence of cardiovascular accidents, with an altered circadian distribution. Abnormalities in the circadian rhythm of autonomic tone may be responsible for this altered temporal onset of cardiovascular disease. METHODS AND RESULTS To assess circadian changes of sympathovagal balance in diabetes, we performed 24-hour power spectral analysis of RR inte...
متن کاملA Possible Explanation for Altered Temporal Onset of Cardiovascular Disease
Background. Diabetic subjects have a high incidence of cardiovascular accidents, with an altered circadian distribution. Abnormalities in the circadian rhythm of autonomic tone may be responsible for this altered temporal onset of cardiovascular disease. Methods and Results. To assess circadian changes of sympathovagal balance in diabetes, we performed 24-hour power spectral analysis of RR inte...
متن کاملDetermination of sensitivity and specificity of QT interval in ECG of diabetic patients for ndiagnosis of cardiac autonomic neuropathy
one of the important complications of diabetes mellitus that physicians pay less attention to is diabetic autonomic neuropathy(DNA) ,especially cardiac autonomic neuropathy (CAN).this has a poor prognosis and is accompanied by sudden death risk,recently several investigations that were carried out for CAN detection ,suggested that QT-interval prolongation in these patients is an important diagn...
متن کاملHeart rate variability: a noninvasive electrocardiographic method to measure the autonomic nervous system.
The autonomic nervous system (ANS) plays an important role not only in physiological situations, but also in various pathological settings such as diabetic neuropathy, myocardial infarction (MI) and congestive heart failure (CHF). Autonomic imbalance associating increased sympathetic activity and reduced vagal tone has been been strongly implicated in the pathophysiology of arrhythmogenesis and...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Clinical science
دوره 61 5 شماره
صفحات -
تاریخ انتشار 1981